Prospective cohort studies using hydrolysed formulas for allergy prevention in atopy-prone newborns: a systematic review.
|Author:||Schoetzau A, Gehring U, Wichmann HE.|
|Title:||Prospective cohort studies using hydrolysed formulas for allergy prevention in atopy-prone newborns: a systematic review.|
|Citation:||European journal of pediatrics. 2001 Jun;160(6):323-32.|
|Abstract:||The aim of this study is to give a systematic overview on publications having
investigated the allergy preventive effect of extensively and/or partially
hydrolysed infant formulas. Publications were searched by several strategies.
Inclusion criteria were: prospective cohort study, randomisation, family history
of atopy of the subjects, follow-up for at least the 1st year of life. Studies
were described systematically as to methods, study participants, interventions
and co-interventions, and study outcomes. The methodological quality was judged according to an instrument assessing the reduction of bias (score between 0 and 7 points). Data of studies having examined partial hydrolysates are presented as odds ratios. Of 16 studies found, 10 fulfilled the inclusion criteria. Study designs showed considerable differences as to methods, intervention and co-intervention procedures and definition of outcomes. Methodological quality varied between 0 and 6 points. The comparison of exclusively test- and coｄｄntrol formula-fed groups showed a uniform tendency towards allergy protection in studies with partial hydrolysates. Study results on the effect of extensive hydrolysates were not comparable because of major differences in study designs.
CONCLUSION: More well-designed studies with an adequate statistical power
are needed to compare the allergy preventive effect of partially and extensively
hydrolysed formulas with a standard infant formula.