非ステロイド性抗炎症薬(NSAIDs)による 即時型食物アレルギーの増強効果 ―わが国における最近 10 年の報告例の検討― /EFFECTS OF NON STEROIDAL ANTIINFLAMMATORY DRUGS (NSAIDs) ON IMMEDIATE-TYPE FOOD ALLERGY ANALYSIS OF JAPANESE CASES FROM 1998 TO 2009
更新日：2016年10月21日
| Author: | Kanako Izumi, Michiko Aihara and Zenro Ikezawa |
|---|---|
| Title: | [Effects of non steroidal antiinflammatory drugs (NSAIDs) on immediate-type food allergy analysis of Japanese cases from 1998 to 2009] |
| Citation: | Japanese Society of Allergology 2009; 58(12):1629―1639 |
| URL: | https://pubmed.ncbi.nlm.nih.gov/20220304/ |
| Abstract: | Background: It is known that an intake of non-steroidal anti-inflammatory drugs (NSAIDs) some- times enhance immediate reactions in patients with food-dependent exercise-induced anaphylaxis (FDEIA). The aim of present study is to evaluate the effects of NSAIDs on food allergy.
Methods: We retrospectively analyzed reports of Japanese patients with immediate-type food al- lergy enhanced by NSAIDs, published in medical Journals from 1999 to 2008. Results: Forty-seven cases containing 5 cases of food allergy induced by foods without exercise and! or NSAIDs, 33 cases of FDEIA, and 9 cases of food allergy induced by foods with NSAIDs but with- out exercise (food-dependent salicylate-induced anaphylaxis; FDSIA) were reported. Ages of all pa- tients except those with FDEIA were more than 20 years. Wheat was the most responsible food in all groups (32!47; 68.1%) and gluten-specific IgE was shown by blood examination, and!or skin tests (prick tests and scratch tests) in 12!23 cases (52%). Aspirin enhanced also skin tests in 7 of 8 cases. Many patients had not recognized the enhance effects of NSAIDs on food allergy before performing provocation tests with causative foods and aspirin. Conclusion: It was shown that NSAIDs enhance the immediate-type reactions due to food allergy and there are some patients who show allergic reaction only when they take the causative foods, and NSAIDs or salicylate together. Patients with food allergy should avoid NSAIDs ingestion with causative foods because the induced symptoms are serious in some patients. |
| 邦文タイトル： | 非ステロイド性抗炎症薬(NSAIDs)による即時型食物アレルギーの増強効果 : わが国における最近10年の報告例の検討 |
| 一般向け要約 | 【背景・目的】食物依存性運動誘発アナフィラキシー(FDEIA)においてNSAIDsは症状の誘発や悪化に関与することが知られている.食物アレルギーにおけるNSAIDsの影響を検討する.【方法】1999年〜2008年におけるNSAIDsの増強効果がみられた即時型食物アレルギー患者の本邦論文報告例の臨床的解析を行った.【結果】全47例中食物摂取のみで症状が誘発されるもの5例,FDEIA33例,食物摂取にNSAIDs投与が加わって症状が誘発されるが食物摂取に運動負荷を加えても発症しないもの9例の報告がみられた.原因食物はいずれの群も小麦が最多であり,グルテン特異的IgE抗体の存在が示されたことからグルテンはNSAIDsの影響を最も受けやすい食物アレルゲンと考えられた.【結語】食物アレルギー反応による症状誘発の閾値がNSAIDsにより低下することが示唆された.FDEIAの一部は食物とNSAIDsで誘発されるが,食物とNSAIDsによる発症に運動の関与しない症例の存在が示された |
| 専門医コメント | アスピリンのようにNSAIDsに分類される薬剤は、食物アレルギー症状を増強させるため服用に際して注意が必要です。 |
