Is there an association between microbial exposure and food allergy? A systematic review

更新日:2016年10月21日

Author:Marrs T, Bruce KD, Logan K, Rivett DW, Perkin MR, Lack G, Flohr C.
Title:Is there an association between microbial exposure and food allergy? A systematic review.
Citation:Pediatric Allergy and Immunology 2013 Jun;24(4):311-320.e8.
URL:https://pubmed.ncbi.nlm.nih.gov/23578298/
Abstract:The environmental factors driving the recent increase in the prevalence of food
allergy (FA) are unclear. Since associations have been demonstrated between
microbial exposure and the likelihood of eczema and respiratory allergies, we
reviewed the evidence for FA. Medline was systematically searched from inception to the end of July 2012 for studies investigating links between FA and
environmental exposures, likely to influence microbial exposure, such as
Caesarean delivery, family size, day-care attendance, childhood infections,
immunizations and antibiotic use. We selected studies reporting food challenge
data, reported doctor-diagnosed (RDD) FA and food sensitization. Methodological differences and study heterogeneity precluded meta-analysis. A total of 46 studies were identified, of which 28 (60.9%) were prospective and 13 (28.3%) used food challenges to diagnose FA. Caesarean delivery was investigated in 13 studies, of which three infant cohorts demonstrated an increase in challenge-proven FA (one cohort) and food sensitization (two cohorts), and one cross-sectional study reported increased RDDFA. Four studies investigated the effect of having siblings, with one infant cohort demonstrating less challenge-proven FA and a cross-sectional study showing a decrease in RDDFA. Attending childcare before 6 months was associated with less challenge-proven FA in one cohort. A cross-sectional survey identified an inverse relationship between hepatitis A serology and peanut sensitization. One of eleven trials investigating probiotics demonstrated a quicker acquisition of milk tolerance amongst allergic infants. Factors influencing microbial exposure may be partly responsible for rising FA burden, but further prospective studies using
double-blind placebo controlled food challenges as an outcome are required.
邦文タイトル:準備中
一般向け要約準備中
専門医コメント準備中